Induction of vascular leakage and blood pressure lowering through kinin release by a serine proteinase from Aeromonas sobria

Aeromonas sobria a Serine Proteinase from Pressure Lowering through Kinin Release by Induction of Vascular Leakage and Blood

Impaired plasma clottability induction through fibrinogen degradation by ASP, a serine protease released from Aeromonas sobria

Aeromonas sobria infection often advances to sepsis, in which interaction of bacterial components with plasma proteins possibly causes various disorders. This bacterium releases a serine protease (ASP), a putative virulence factor, and binds to fibrinogen. To study the ASP effect on fibrinogen, we incubated fibrinogen or plasma with ASP and investigated their clotting elicited by thrombin, whic...

Induction of vascular leakage through release of bradykinin and a novel kinin by cysteine proteinases from Staphylococcus aureus

Staphylococcus aureus is a major pathogen of gram-positive septic shock and frequently is associated with consumption of plasma kininogen. We examined the vascular leakage (VL) activity of two cysteine proteinases that are secreted by S. aureus. Proteolytically active staphopain A (ScpA) induced VL in a bradykinin (BK) B(2)-receptor-dependent manner in guinea pig skin. This effect was augmented...

Aeromonas sobria Released from Production of C5a by ASP, a Serine Protease

Blood Pressure Lowering by Pioglitazone

Thomas A. Buchanan,* Woemer P. Meehan,* Young Y. Jeng,t Dong Yang,* Timothy M. Chan,* Jerry L. Nadler,§ Steven Scott,§ Robert K. Rude,* and Willa A. Hsueh* *Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, School of Medicine and *Department of Toxicology, School of Pharmacy, University of Southern California Medical Center, Los Angeles, California 90033; and §Divisi...